The Twenty20 match, accorded international status by the International Cricket Council, is the first game of only the second series Pakistan has hosted since militants attacked the bus of the visiting Sri Lankan team in March 2009, killing eight people and injuring seven players and staff.
The Pakistan team will lock horns with the Faf du Plessis led ICC World XI in the second match of the series on Wednesday.
In the first T20I Pakistan was sent into bat by World XI skipper Faf du Plessis, notched 197-5 with Babar Azam hitting a rapid 52-ball 86. His career best Twenty20 score had ten boundaries and two sixes.
Azam added 122 for the second wicket with Ahmed Shehzad (39) as Pakistan built on the loss of opener Fakhar Zaman for eight.
Shoaib Malik smashed a 20-ball 38 with two sixes and four boundaries to give the final touches to the innings.
The World XI started off well with Tamim Iqbal hitting 18 with three boundaries and Hashim Amla smashing three boundaries and a six in his 17-ball 26 but left-arm pacer Rumman Raees dismissed both in the same over to put the brakes on their innings.
Skipper Faf du Plessis hit four boundaries and a six while Darren Sammy smashed three sixes -- both scoring 29 -- but were unable to see their team through.
For Pakistan, paceman Sohail Khan and leg-spinner Shadab Khan finished with two wickets apiece.
World XI: Tamim Iqbal, Hashim Amla, Tim Paine(w), Faf du Plessis(c), David Miller, Paul Collingwood, Thisara Perera, Ben Cutting, Samuel Badree, Morne Morkel, Imran Tahir
Pakistan: Fakhar Zaman, Ahmed Shehzad, Babar Azam, Shoaib Malik, Sarfraz Ahmed(w/c), Imad Wasim, Mohammad Nawaz, Shadab Khan, Sohail Khan, Usman Khan, Rumman Raees