Diabetes drug may restore memory in Alzheimer patients
Researchers showed that a diabetes drug that never made it to market could block the toxic effects of a protein that leads to brain-cell death.
Toronto: A drug intended for diabetes appears to restore memory in brain cells affected by Alzheimer's disease, researchers say. Medical researchers at the University of Alberta led by Jack Jhamandas took brain tissue from animal models with Alzheimer's disease and tested the tissue in the lab, looking specifically at the cells' memory capacity.
When brain cells are shocked by a barrage of electrical impulses, the cells "remember" the experience, which is a typical way to test or measure memory in the lab setting. Amyloid protein, which is found in abnormally large amounts in the memory and cognition parts of the brains of Alzheimer's patients, diminishes memory.
A sister protein, known as amylin, which comes from the pancreas of diabetic patients, has the same impact on memory cells. Jhamandas and his team demonstrated last year that a diabetes drug that never made it to market, known as AC253, could block the toxic effects of amyloid protein that lead to brain-cell death.
In the lab, Jhamandas and his teammates, including Ryoichi Kimura, a visiting scientist from Japan, tested the memory of normal brain cells and those with Alzheimer's both from animal models. When the drug AC253 was given to brain cells with Alzheimer's and the shock memory tests were redone, memory was restored to levels similar to those in normal cells.
"This is very important because it tells us that drugs like this might be able to restore memory, even after Alzheimer's disease may have set in," Jhamandas said in a statement. His team is continuing their research in this area and want to see whether the drug, when given before symptoms appear, can "stop the impairment of behaviour and cognition altogether in animals destined to develop Alzheimer's".
He also noted it is difficult for AC253 to cross the brain barrier, so research teams in pharmaceutical companies would need to design a similar drug that can penetrate brain cells more easily.
Jhamandas said if the tests are successful, clinical trials could start within about five years, but he stressed that further testing needs to be done before such trials can occur. The study was published in the Journal of Neuroscience.