Vesely came out on top in a battle of left-handed qualifiers to claim his maiden ATP tour title with a 6-3, 6-2 victory.
The Auckland Open suffered a double blow when third seed Roberto Bautista Agut withdrew during his second round match against Adrian Mannarino.
Isner claimed his second Auckland Open title with a 7-6(4) 7-6(7) victory over an inspired Lu Yen-Hsun in a tight final.
Ferrer underlined his Australian Open threat by thrashing Gael Monfils 6-1, 6-2 to reach the final.
Top-seeded David Ferrer won the Heineken Open for the third time when he beat unseeded Olivier Rochus.
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