South Africa's Titans and England's Hampshire were allowed to replace their injured players.
Defending 111, England beat Pakistan by 15 runs thanks to a superb bowling effort.
England defeated South Africa by 28 runs in the 3rd T20 at Edgbaston, Birmingham to level the three-match series 1-1.
Paceman Tim Bresnan also returns to the 16-man squad after missing the Test series due to elbow injury.
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