Defending title-holder, Maria Sharapova of Russia fell short of repeating last year's magic and came out second best in the 112th edition of the French Open.
Williams whacked 10 aces, including three in the final game to extend her career-best winning streak to 31 matches. Here, she celebrates the match point against Sharapova on Saturday.
Sharapova had to dig in hard to hold at the start of set two, fending off five break points, and it was all downhill for her from there.
Serena Williams and Maria Sharapova pose with their respective titles after the women's final of the French Open 2013 on Saturday.
Serena Williams of USA won her 16th Grand Slam title and her first French Open championship since 2002 when she beat familiar foil Maria Sharapova 6-4, 6-4 on Saturday.
Michael Llodra and Nicolas Mahut of France came close but couldn't get over the finish line as they were declared the runners-up of the men's doubles.
In the tiebreaker, the Bryans rallied from a 4-2 deficit to clinch the victory when Mahut sent a forehand wide. The twins won their only other French Open in 2003
Llodra and Mahut were bidding to become the first Frenchmen to win the doubles since Yannick Noah and Henri Leconte in 1984.
In another fixture, top-seeded Bob and Mike Bryan of the United States won their 14th major doubles title by defeating Michael Llodra and Nicolas Mahut of France 6-4, 4-6, 7-6 (4) in the French Open final Saturday.