Day 2 Summary: James Anderson took four wickets from the newly-named James Anderson End to leave England in a commanding position against South Africa in the fourth Test at Old Trafford on Saturday.
South Africa were 220 for nine in reply to England's first innings 362, featuring Jonny Bairstow's 99, at stumps on the second day.
That left them with a deficit of 142 runs in a match they have to win to draw this four-match series 2-2.
Morne Morkel was 18 not out after Kagiso Rabada (23) was brilliantly caught by a diving Ben Stokes in the gully off Stuart Broad in what became the last ball of the day.
At stumps, paceman Anderson had figures of four wickets for 33 runs in 15 overs.
The 35-year-old was now in sight of his first five-wicket haul in a Test innings at Old Trafford.
But his seventh Test at Old Trafford was the first fixture since what was known as the Pavilion End had been renamed in honour of Anderson, England's all-time leading Test wicket-taker.
Anderson needed just three balls to strike when Dean Elgar, fresh from a hundred in South Africa's 239-run defeat in the third Test at The Oval, was lbw for a duck in the first over of the Proteas' reply.