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South Africa did not make it out of the group stage of the eight-team Champions Trophy, their fate sealed with a thumping defeat by India at The Oval.
England too were undone in their quest for Champions Trophy glory with a semi-final defeat by eventual champions Pakistan.
Now England and South Africa meet in a three-match Twenty20 series, starting at Southampton on Wednesday.
De Villiers's captaincy was called into question during the Champions Trophy but now he is ready to lead the side at the 2019 World Cup in England.
"I'm very excited to play in the three T20s, it was a tough few days after being knocked out of the Champions Trophy," said de Villiers at Southampton on Tuesday.
"To go through that phase of reflecting and hearing some of the criticism. It is never easy but I have always been the kind of guy to see the positives and see opportunity to improve and these three matches give me that opportunity as a player and a captain.
"I don't feel I have to prove anything; I just want to play, I feel like a youngster starting my career. I just want to score some runs again and captain this side to a couple of wins.
"We learnt a lot of things when it comes to playing cricket here (in England). Pakistan surprised all of us how they controlled the middle overs. We have taken some cricket things out of it but also from the mental point of view.
In the three-match ODI series prior to the Champions Trophy, South Africa lost 1-2.
Catch all the Live action from the first T20I between England and South Africa in Southampton.
England: Eoin Morgan(c), Jonny Bairstow, Sam Billings, Jos Buttler(w), Mason Crane, Tom Curran, Liam Dawson, Alex Hales, Chris Jordan, Liam Livingstone, Dawid Malan, Jason Roy, Craig Overton, Liam Plunkett, David Willey, Mark Wood
South Africa: AB de Villiers(c), Farhaan Behardien, Reeza Hendricks, David Miller, Mangaliso Mosehle(w), Chris Morris, Dane Paterson, JJ Smuts, Wayne Parnell, Andile Phehlukwayo, Imran Tahir, Dwaine Pretorius, Morne Morkel, Tabraiz Shamsi
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