At the close of play, Vidarbha were comfortably placed at 431 for six, with an overall lead of 501 runs.
Resuming on 77 for one, overnight batsman Fazal, starting at a personal score of 51, went on score a 209-ball 119 that included 15 hits to the fence.
Wasim Jaffer (58) and Ganesh Satish (65) then contributed with half-centuries each, while lower-order batsman Wankhade's quickfire 107 that came off just 94 deliveries, studded with six boundaries and five sixes, put the hosts in the driver's seat.
Akshay Wadkar was batting on 20 and Karn Sharma was unbeaten on 4 when the stumps were drawn.
With Vidarbha already having taken a first-innings lead, they have all but made it to the semifinals.
For Kerala, Jalaj Saxena chipped in with three for 106.
Brief scores: Vidarbha: 246 & 431/6 in 124 overs (Faiz Fazal 119, Apoorv Wankhade 107, Ganesh Satish 65, Wasim Jaffer 58; Jalaj Saxena 3/106). Kerala 1st innings: 176 all out.
First Published: December 10, 2017, 8:31 PM IST