After winning the five-match ODI series 3-1, India will certainly have an upperhand despite the presence of Gayle, who can single-handedly swing fortunes especially in the shortest format.
However, Gayle will be donning the Caribbean maroons after a gap 15 months during which he has battled injuries as well as poor form during the IPL, which was his last competitive tournament before this particular game.
West Indies are reigning world champions with the likes of Gayle, Marlon Samuels, Sunil Narine and Samuel Badree still a part of the current squad led by their World T20 hero Carlos Brathwaite.
Also there's Evin Lewis, who had scored a 49-ball-100 in West Indies' one-run win over India in a T20 game in Florida, last year.
But T20 is one format where the home team starts on even keel against an Indian team which had its foot firmly on the pedal save an occasional blip in Jamaica.
India: Virat Kohli (captain), Shikhar Dhawan, Ajinkya Rahane, Mahendra Singh Dhoni (wk), Yuvraj Singh, Kedar Jadhav, Hardik Pandya, Rishabh Pant, Ravindra Jadeja, Ravichandran Ashwin, Kuldeep Yadav, Bhuvneshwar Kumar, Umesh Yadav, Dinesh Karthik, Mohammed Shami.
West Indies: Carlos Brathwaite (capt), Samuel Badree, Ronsford Beaton, Chris Gayle, Evin Lewis, Jason Mohammed, Sunil Narine, Kieron Pollard, Rovman Powell, Marlon Samuels, Jerome Taylor, Chadwick Walton (wk), Kesrick Williams.