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Double Virus Strain First Detected in Oct, But its Gene Study was Stalled; A Triple Mutant Appears: Report

Representational image

Representational image

The Health Ministry was last week briefed about the possibility of this double mutant variant developing another significant mutation and becoming a 'triple-mutant.'

The double mutant strain of coronavirus that many experts say is behind the recent rapid surge of second Covid wave was first detected in October 5 last year through genome sequencing of a virus sample.

A report in the Indian Express said that since both the mutations, E484Q and L425R, were located in the virus’s critical spike protein — that binds it to the receptor cells in the body. The destructive potential of the mutant should have raised red flags and led to widespread gene surveillance to look for its spread.

However, the slow pace of the genome sequencing exercise got further slowed down between November and January due to lack of funds, absence of clear directives and disinterest because of the falling Covid curve.

With Covid cases skyrocketing with every passing day, India has already surpassed Brazil to be the second worst-affected and has already begun to overwhelm the hospitals and crematoriums.

The report said that a third mutation in the B.1.167 has been identified now and experts are hoping that this time the pace of intervention and follow-up picks up.

Genome sequencing, the study of genetic structures of an organism and the changes happening in it, give information about the virus’ origins, routes taken to reach a particular area and the changes, or mutations, that are making the virus stronger or weaker.

India, in the first six months, barely conducted a few hundred genome sequencing, while other countries like China, the UK and US, had done several thousand and submitted these in public global depositories for scientists across the world to study.

It was only in December last year that the government announced setting up the Indian SARS-CoV2 Genomics Consortium (INSACOG) to expedite the gene sequencing effort from India through a consortium of 10 laboratories.

The CCMB, which is one of the labs under INSACOG, discovered the double mutant during genome sequencing last month. CCMB Director Rakesh Mishra earlier this month said that the double mutant found in Maharashtra is a matter of concern, but not a cause to create panic. He had added that he cannot link double mutant to the surge in cases in Maharashtra during that stage.

“The whole point of gene sequencing is to remain ahead of the curve, anticipate what new variants of the virus are likely to emerge, how they are likely to behave, and what can be done to contain their spread in the population. More the sequences, greater is our information about them, and more effective our response can be,” a scientist associated with the sequencing effort reportedly said.

“Unfortunately, India has been well behind the curve on this front. We have been reacting to the developments, instead of anticipating it,” he added.

Gene sequencing is time-consuming and costly as it can take three to five days to develop one sequence. A few government laboratories have been doing the gene sequencing work, which involves a huge amount of computer processing time. Moreover, developing one sequence can cost between Rs 3-5000.

The report quoted multiple sources saying that the Health Ministry was last week briefed about the possibility of this double mutant variant developing another significant mutation and becoming a “triple-mutant.” It added that three different varieties have been detected.

Two of the triple-mutant varieties have been found in samples collected from Maharashtra, Delhi, West Bengal and Chhattisgarh.

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first published:April 20, 2021, 10:58 IST