Take the pledge to vote

For a better tommorow#AajSawaroApnaKal
  • I agree to receive emails from News18

  • I promise to vote in this year's elections no matter what the odds are.
  • Please check above checkbox.

    SUBMIT

Thank you for
taking the pledge

Vote responsibly as each vote counts
and makes a diffrence

Disclaimer:

Issued in public interest by HDFC Life. HDFC Life Insurance Company Limited (Formerly HDFC Standard Life Insurance Company Limited) (“HDFC Life”). CIN: L65110MH2000PLC128245, IRDAI Reg. No. 101 . The name/letters "HDFC" in the name/logo of the company belongs to Housing Development Finance Corporation Limited ("HDFC Limited") and is used by HDFC Life under an agreement entered into with HDFC Limited. ARN EU/04/19/13618
News18 » India
1-min read

Nearly 70 Drugs That May be Effective Against COVID-19 Identified

Some viral proteins seemed to target just one human protein, while others are capable of targeting a dozen human cellular proteins, the researchers explained.

PTI

Updated:March 26, 2020, 5:07 PM IST
facebookTwitter Pocket whatsapp
Nearly 70 Drugs That May be Effective Against COVID-19 Identified
Image for representation only. (PTI)

New Delhi: An international team, including scientists of Indian origin, has identified 69 drugs and experimental compounds which may be effective in treating COVID-19.

According to the researchers, some of the medications are already used to treat diseases such as diabetes and hypertension, and repurposing them to treat COVID-19 may be faster than trying to invent a new vaccine.

In the new study, published on the pre-print website bioRxiv, the scientists investigated 26 of the 29 coronavirus genes, which direct production of the viral proteins.

"The team took a different approach, targeting host proteins, not viral proteins. 26 out of 29 SARS-CoV-2 viral proteins were studied in human cells to find out what human proteins they interact with," Gina T Nguyen, Assistant Director of Communications & Events, Quantitative Biosciences Institute, University of California, San Francisco (UCSF) in the US, told PTI in an email.

Around 332 human proteins were found to interact with the SARS-CoV-2 viral proteins, the researchers, including Advait Subramanian, Srivats Venkataramanan, and Jyoti Batra, all from UCSF, said.

These are the proteins that the virus, which has killed over 2,1000 people and infected more than 4,71,000 globally so far, relies on to

reproduce and carry out the infection in people, they said.

"69 drugs were identified that can target these proteins, of which 25 are already US Food and Drug Administration (FDA) approved and could be used off-label.

"The drugs identified include those that are safely taken to treat conditions such as: Type II diabetes, cancer, and hypertension," Nguyen said.

Some viral proteins seemed to target just one human protein, while others are capable of targeting a dozen human cellular proteins, the researchers explained.

They noted that there are currently no antiviral drugs with proven efficacy, nor are there vaccines for preventing COVID-19.

"Unfortunately, the scientific community has little knowledge of the molecular details of SARS-CoV-2 infection," the team wrote in an abstract.

The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains, according to the researchers.

Support the daily wage earners who have been hit the hardest by the COVID-19 crisis. Click here to contribute to the cause. #IndiaGives

The daily News18 Coronavirus COVID-19 newsletter - Get your copy here.

Subscribe to News18 Daybreak. Follow us on Twitter, Instagram, Facebook, Telegram, TikTok and on YouTube

Read full article

Live TV

Countdown To Elections Results
To Assembly Elections 2018 Results

India

  • Active Cases

    3,666

     
  • Total Confirmed

    4,067

     
  • Cured/Discharged

    291

     
  • Total DEATHS

    109

     
Data Source: Ministry of Health and Family Welfare, India
Updated: April 06 (09:00 AM)
Hospitals & Testing centres

World

  • Active Cases

    941,228

     
  • Total Confirmed

    1,277,259

     
  • Cured/Discharged

    266,461

     
  • Total DEATHS

    69,570

     
Data Source: Johns Hopkins University, U.S. (www.jhu.edu)
Hospitals & Testing centres