Take the pledge to vote

For a better tommorow#AajSawaroApnaKal
  • I agree to receive emails from News18

  • I promise to vote in this year's elections no matter what the odds are.
  • Please check above checkbox.

    SUBMIT

Thank you for
taking the pledge

Vote responsibly as each vote counts
and makes a diffrence

Disclaimer:

Issued in public interest by HDFC Life. HDFC Life Insurance Company Limited (Formerly HDFC Standard Life Insurance Company Limited) (“HDFC Life”). CIN: L65110MH2000PLC128245, IRDAI Reg. No. 101 . The name/letters "HDFC" in the name/logo of the company belongs to Housing Development Finance Corporation Limited ("HDFC Limited") and is used by HDFC Life under an agreement entered into with HDFC Limited. ARN EU/04/19/13618
LIVE TV DownloadNews18 App
News18 English
News18 » India
1-min read

Researchers Reveal How Bacteria Causing Hospital-borne Infections Resist Antibiotics

The researchers at Imperial College London have found that one mechanism by which infectious bacteria resist drug treatment was to shut out tiny doors on their cell walls that allow the entry of certain chemicals - including antibiotics.

PTI

Updated:September 2, 2019, 6:51 PM IST
facebookTwitterskypewhatsapp
Researchers Reveal How Bacteria Causing Hospital-borne Infections Resist Antibiotics
Representative image. (Image: Reuters)
Loading...

London: Researchers in the UK have discovered one of the important mechanisms by which bacteria causing hospital-borne illnesses are becoming resistant to antibiotics, an advance that may help in designing new drugs.

The researchers at Imperial College London have found that one mechanism by which infectious bacteria resist drug treatment was to shut out tiny doors on their cell walls that allow the entry of certain chemicals - including antibiotics.

For long, researchers across the world have tried to understand how bacteria spreading and causing untreatable infections from hospitals have been able to resist drug treatment.

According to the study, antibiotics usually enter the K pneumoniae bacteria through surface doorways known as pores.

On investigating the structure of the pores, the team showed shutting these doorways makes K pneumoniae resistant to multiple drugs, and antibiotics cannot enter and kill them.

"The prevalence of antibiotic resistance is increasing, so we are becoming more and more reliant on drugs like Carbapenems that work against a wide range of bacteria," said the first author of the paper Joshua Wong.

"But now with important bacteria like K pneumoniae gaining resistance to Carbapenems it's important we understand how they are able to achieve this. Our new study provides vital insights that could allow new strategies and drugs to be designed," he added.

Wong and his team compared the structures of K pneumoniae bacteria that were resistant to Carbapenems with those that were not.

The team found that the resistant bacteria had a different or absent version of a protein that makes up their cell wall pores. Particularly, the resistant bacteria had much smaller pores, and

was blocking antibiotics from entering the cell.

Professor Gad Frankel, who led the team, said that the modification seen in the bacteria to avoid antibiotics was difficult to get around.

"Any drugs to counteract this defence mechanism would likely also get blocked out by the closed doors," he added.

"However, we hope that it will be possible to design drugs that can pick the lock of the door, and our data provide information to help scientists and pharmaceutical companies make these new agents a reality," Frankel said.

The study provides direct scientific evidence that the implementation of restrictive prescribing policies of broad-spectrum agents such as Carbapenems in hospitals is needed to combat

antibiotic resistance.

The new findings were published in the journal Nature Communications.

Get the best of News18 delivered to your inbox - subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, TikTok and on YouTube, and stay in the know with what's happening in the world around you – in real time.

Read full article
Loading...
Next Story
Next Story

Also Watch

facebookTwitterskypewhatsapp

Live TV

Loading...
Countdown To Elections Results
To Assembly Elections 2018 Results