Take the pledge to vote

For a better tommorow#AajSawaroApnaKal
  • I agree to receive emails from News18

  • I promise to vote in this year's elections no matter what the odds are.
  • Please check above checkbox.

    SUBMIT

Thank you for
taking the pledge

But the job is not done yet!
Vote for the deserving candidate this year.

Check your mail to know more

Disclaimer:

Issued in public interest by HDFC Life. HDFC Life Insurance Company Limited (Formerly HDFC Standard Life Insurance Company Limited) (“HDFC Life”). CIN: L65110MH2000PLC128245, IRDAI Reg. No. 101 . The name/letters "HDFC" in the name/logo of the company belongs to Housing Development Finance Corporation Limited ("HDFC Limited") and is used by HDFC Life under an agreement entered into with HDFC Limited. ARN EU/04/19/13618
SPONSORED BY
LIVE TV DownloadNews18 App
News18 English
Powered by cricketnext logo

Iron Overload Drug Might Improve Leukaemia Treatment

A new study suggests that chemotherapy for one type of leukaemia could be improved by giving patients a drug currently used in the treatment of iron overload.

IANS

Updated:December 27, 2017, 11:22 AM IST
facebookTwittergoogleskypewhatsapp
Iron Overload Drug Might Improve Leukaemia Treatment
Representative Image. (Image: Getty Images)
Loading...
London: Chemotherapy for one type of leukaemia could be improved by giving patients a drug currently used in the treatment of iron overload, new research has showed.

Acute myeloid leukaemia (AML) is an aggressive cancer that stops healthy blood cell production. Chemotherapy is the standard treatment, but improvements are needed as the five-year survival rate in patients older than 60 is only 5-15 per cent.

The findings, from Imperial College London, showed that special regions of blood vessels where blood stem cells -- that generate billions of new cells every day of our life -- reside are the hardest hit by leukaemia.

When these are overtaken by leukaemia cells, the stem cells are lost and production of healthy blood is significantly reduced, causing anaemia, infection, and bleeding in patients. It allows the disease to progress as well as affects the success of chemotherapy.

In the study, published in the journal Cell Stem Cell, the team tested a drug called deferoxamine -- used to treat iron overload, which can happen for example when a person receives multiple blood transfusions.

Deferoxamine, which is already approved to treat iron overload, was found to have a protective effect on the blood vessels in AML patients, allowing the rescue of healthy blood stem cells.

Moreover, the enhanced vessels also improved the efficiency of chemotherapy.

"Since the drug is already approved for human use for a different condition, we already know that it is safe," said lead author Cristina Lo Celso from the varsity.

"We still need to test it in the context of leukaemia and chemotherapy, but because it is already in use we can progress to clinical trials much quicker than we could with a brand new drug," Celso added.

For the study, the team filmed the invasion of leukaemia cells into bone marrow in mice, which allowed them to see details of the bone marrow, revealing phenomena happening deep inside the bone marrow.

The researchers are now hoping to begin human trials of the drug for AML.
| Edited by: Manila Venugopal
Read full article
Loading...
Next Story
Next Story

Also Watch

facebookTwittergoogleskypewhatsapp
 
T&C Apply. ARN EU/04/19/13626
 

Live TV

Loading...
Countdown To Elections Results
  • 01 d
  • 12 h
  • 38 m
  • 09 s
To Assembly Elections 2018 Results