Take the pledge to vote

For a better tommorow#AajSawaroApnaKal
  • I agree to receive emails from News18

  • I promise to vote in this year's elections no matter what the odds are.
  • Please check above checkbox.

    SUBMIT

Thank you for
taking the pledge

Vote responsibly as each vote counts
and makes a diffrence

Disclaimer:

Issued in public interest by HDFC Life. HDFC Life Insurance Company Limited (Formerly HDFC Standard Life Insurance Company Limited) (“HDFC Life”). CIN: L65110MH2000PLC128245, IRDAI Reg. No. 101 . The name/letters "HDFC" in the name/logo of the company belongs to Housing Development Finance Corporation Limited ("HDFC Limited") and is used by HDFC Life under an agreement entered into with HDFC Limited. ARN EU/04/19/13618
LIVE TV DownloadNews18 App
News18 English

Targeted Cancer Treatments Far Outperform Traditional Methods

Researchers in Texas began studying the impact of these therapies in 2007, after seeing the success of Gleevec (imatinib) -- a breakthrough drug approved by US regulators in 2001 that showed huge success against chronic myeloid leukemia.

AFP Relaxnews

Updated:June 3, 2018, 12:51 PM IST
facebookTwitterskypewhatsapp
Targeted Cancer Treatments Far Outperform Traditional Methods
(Photo courtesy: AFP Relaxnews/ FatCamera / Istock.com)
Loading...

Cancer treatments that attack tumors based on their individual genetic traits -- not their location in the body -- far outperform traditional methods, extending survival for twice as many patients, a study said Saturday.

The precision medicine field of targeted therapy involves testing tumors for clues about their genetic mutations, and matching patients with new drugs designed to block cancer's growth on a molecular level.

Researchers in Texas began studying the impact of these therapies in 2007, after seeing the success of Gleevec (imatinib) -- a breakthrough drug approved by US regulators in 2001 that showed huge success against chronic myeloid leukemia.

The results of the first and largest precision medicine trial to look at survival across a host of cancer types and many different targeted therapies were released at the American Society of Clinical Oncology meeting in Chicago, the world's largest annual cancer meeting. The study, called IMPACT, enrolled 3,743 patients at Texas MD Anderson Cancer Center from 2007 to 2013.

All the patients had advanced cancers, or "end-stage disease," involving cancers of the gastrointestinal tract, breast, or lung. Melanoma and cancer of the female reproductive tract were also included, along with more rare types of cancer.

Those enrolled had typically tried at least four -- and sometimes up to 16 -- other treatments that failed to halt the growth of their cancer.

Patients who received molecular targeted therapies either got an investigational drug then being tested in a clinical trial, or an FDA-approved targeted therapy commercially approved for another indication.

After three years, 15 percent of people treated with targeted cancer therapies were alive, compared to seven percent in the non-targeted group. After 10 years, six percent of the targeted group was alive, compared to just one percent in the other group.

On the whole, targeted therapies led to an average of four months of life without the cancer advancing, known as progression-free survival, and nine extra months of overall survival. Those who were treated with traditional approaches lived just under three months without cancer growing, and 7.3 months longer overall. Researchers say the field has grown immensely since 2007, and that further research will improve the range of therapies available to cancer patients.

"When IMPACT first opened, we tested for no more than one to two genes," said lead investigator Apostolia Tsimberidou, professor of investigational cancer therapeutics at MD Anderson. "Now patients are being tested for hundreds of actionable genes, amplifications and mutations, as well as for immune markers," she added, noting, "Ideally, in the future, patients' tumor testing and cell-free DNA analysis will become the standard of care at the time of diagnosis, in hopes of making a difference for patients upfront, especially in those with hard-to-treat cancers."

Get the best of News18 delivered to your inbox - subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, TikTok and on YouTube, and stay in the know with what's happening in the world around you – in real time.

Subscribe to Moneycontrol Pro and gain access to curated markets data, trading recommendations, equity analysis, investment ideas, insights from market gurus and much more. Get Moneycontrol PRO for 1 year at price of 3 months. Use code FREEDOM.

Read full article
Loading...
Next Story
Next Story

Also Watch

facebookTwitterskypewhatsapp

Live TV

Loading...
Countdown To Elections Results
To Assembly Elections 2018 Results