Manchester: Wayne Rooney was seen training with his Manchester United team-mates on Wednesday, a day before their Europa League tie away to Belgian side Anderlecht.
The England striker missed United's last two Premier League matches, against Everton and Sunderland, with an ankle injury but was involved in the session at the English giants' Carrington training ground.
Spanish goalkeeper de Gea missed Sunday's 3-0 win over Sunderland with a hip problem.
United manager Jose Mourinho may opt to keep de Gea out of action come Thursday's quarter-final first leg match in Brussels and bring him back for this weekend's league fixture against leaders Chelsea instead.
That would mean Sergio Romero continuing between the posts against Anderlecht.United, who've yet to win the Europa League, have won all three of their previous ties with Anderlecht.