Mario Pasalic scored a hat-trick and Marten de Roon, Ruslan Malinovsky, Duvan Zapata all netting one each to help Atalanta beat Bresica 6-2 in the Serie A.
Fourth-placed Atalanta will face Brescia on July 15, Wednesday, in the Serie A 2019-20.
Cristiano Ronaldo scored from the penalty spot twice to help Serie A leaders Juventus to a 2-2 draw against Atalanta.
Serie A 2019-20 Live Streaming: Juventus vs Atalanta will be played at Allianz Stadium.
The Champions League draw for the final eight will be held as planned with four last-16 ties still to be completed and doubt over holding the final in Lisbon
Atalanta with the win over sixth-place Napoli are 15 points ahead and 12 in front of Roma who lost to Udinese in Serie A
Serie A: Inter Milan turned it around late against Parma to win 2-1; Atalanta registered a 3-2 win at Udinese.
Title-chasing Lazio suffered their first Serie A defeat in nine months, falling 3-2 at Atalanta on Wednesday to stay four points behind leaders Juventus after surrendering a two-goal lead.
Serie A 2019-20: Atalanta returned to Serie A football with a 4-1 win over Sassuolo while Inter Milan beat Sampdoria 2-1.
Serie A 2019-20: Juventus' hold on the title in under threat with recent final losses in picture and the team being just a point ahead of Lazio.
A huge controversy took birth when Atalanta coach Gian Piero Gasperini admitted to having coronavirus symptoms when his team played Champions League match vs Valencia in March.
He also confirmed he has since tested positive from an antibodies test.
Gian Piero Gasperini said the thought of going to the hospital overflowing with coronavirus patients was a scary one.
Italian football bosses are hopeful that Italy can follow the German Bundesliga, which has already returned to the pitch, and Spain's La Liga which prepares to kick off again on June 8.
19-year-old Andrea Rinaldi suffered brain aneurysm three days ago while training and passed away on Monday.
Experts are calling the February 19 game where Atalanta faced Valencia in the UEFA Champions League at Milan's San Siro.
UEFA Champions League 2019-20: Atalanta crushed Valencia 8-4 on aggregate in the Round of 16 to make their first quarter-finals.
Serie A 2019-20: Six matches were postponed due to coronavirus outbreak but Atalanta smacked Lecce 7-2 while AS Roma edged past Cagliari 4-3.
Inter Milan's clash against Sampdoria, Atalanta against Sassuolo and Hellas Verona versus Cagliari was postponed to avoid the spread of the virus with 79 confirmed cases and 2 death due to Coronavirus.
UEFA Champions League 2019-20: Atalanta took a step towards reaching the quarters on their competition debut as they crushed Valencia 4-1 in last 16 first leg.