The Briton has been out of action since he injured his left ankle while playing soccer with friends earlier this month.
Rory McIlroy will not defend his British Open title at St Andrews next week after announcing on Wednesday he did not want to risk further damage to the ankle ligaments he ruptured playing football last weekend.
McIlroy's title defence and keenly anticipated contest against Spieth was thrown into doubt on when the Northern Irishman revealed he had ruptured an ankle ligament.
McIlroy's defence of golf's British Open has been thrown into doubt after he said on Monday that he had ruptured ankle ligaments in a friendly football match with his friends.
McIlroy's defence of golf's British Open has been thrown into doubt after he said he had ruptured ankle ligaments in a friendly football match with his friends.
"The amazing thing about this group of players is that we've come on tour and we've been ready to win from the start," said McIlroy,
McIlroy wasted little time after missing the cut for a third straight year at the Irish Open as he headed straight for his parents' Belfast home on Friday.
McIlroy's back-nine 42 was riddled with errors and a miserable three-putt effort from 20 feet at the last hole meant he plunged to a six-over 78 and a five-over tally of 149.
After his runaway 7-stroke victory at the Wells Fargo Classic, McIlroy plans to get as much rest as possible before he competes at BMW Masters next week.
"I don't know if you call that intimidation but I feel when players see my name on the leaderboard now it might mean a little bit more than it used to," said McIlroy.
McIlroy is confident he can add two majors to his trophy haul this year after a successful 12 months in which he has proved himself to be the world's best player.
McIlroy drew comparisons with Tiger Woods after the Northern Irishman's stunning round of 11-under 61 at the Wells Fargo Championship.
McIlroy does not usually play five successive weeks of tournament golf, but he could not resist returning to the site of his first PGA Tour victory for this week's Wells Fargo Championship.
Retired tennis star Li Na is up against Serena Williams in a six-woman field for sportswoman of the year in the Laureus Sports Awards.
Speith made four birdies in five holes on the back nine to stretch his lead to seven shots to seize control of the Masters.
Jordan Spieth broke the 36-hole Masters record that had stood for 39 years. His five-shot lead matched another Masters record.
McIlroy and Tiger Woods dominated the build-up to this week's Masters but it was Spieth who produced the fireworks in a gripping opening round at Augusta National on Thursday.
McIlroy is trying to complete the career Grand Slam while Woods is looking to play 72 holes in a regular PGA Tour event.
"I don't think Rory can ever beat Tiger," said the major champion and former winning U.S. Ryder Cup captain Paul Azinger.
It was only a practice round on the Monday of Masters week, but it gave hope that the four-time winner of the green jacket might still be capable of major championship magic.