Udinese and former Italy striker Antonio di Natale said he would retire at the end of the season.
Fernando Llorente scored a stoppage-time winner to help Juventus snatch a 1-0 win over Udinese and stretch their lead at the top.
Juventus eased to a 2-0 win at Livorno to provisionally take over the top spot in Serie A, while Fiorentina fell to a surprise 1-0 defeat at Udinese.
Bradley scored late to help 10-man Roma beat Udinese 1-0 and set a Serie A record by winning their first nine matches of the season.
Elsewhere, Gonzalo Higuain converted two controversial penalties to help Napoli beat 10-man Torino 2-0, while Juventus beat Genoa by the same scoreline.
Injury-hit AC Milan edged visiting Udinese 1-0 for just their third win in eight Serie A matches on Saturday.
Balotelli has reported a muscular pain in his right thigh," a statement from the Milan club read on Thursday.
The 57-year-old Guidolin has been at Udinese since 2010 and the club has taken great strides under him.
Di Natale had been linked with a move to AC Milan but the former Italy striker penned a new contract on Tuesday.
A spectacular scissor-kick strike from Antonio Di Natale gave Udinese a 1-0 win over Lazio as they moved level on points with them in the Serie A.
Mario Balotelli marked his return to Serie A by scoring both goals - including the winner in added time - in AC Milan's 2-1 win.
Juventus got back to winning ways with a 4-0 win over Udinese in the Serie A with two stunning goals from Pogba.
Italy forward Antonio Di Natale scored twice to help Udinese beat 10-man Inter Milan 3-0 Sunday.
Klose scored the only goal 8 minutes from time to extend Lazio's unbeaten streak to nine in all competitions.
Liverpool survived a late scare to move into the last 32 of the Europa League with a 1-0 win over Udinese.
Lazio moved back within striking distance of third place and the final Champions League place with a 3-0 win over Udinese.
Meanwhile, Inter Milan recorded a 3-1 win at Neftci of Azerbaijan, scoring all their goals in the first half.
Alexis Sanchez gave himself five out of 10 when asked to rate his first year with the Spanish soccer giants.
Massimiliano Allegri has been handed a one-match ban for insulting the referee at the end of Sunday's 2-1 defeat at Udinese.