In 2006, she appeared in 'Bobby' which featured an all-star cast, including her husband Ashton Kutcher, although they did not appear in any scenes together.
On the personal front, in 1980, at the age of 18, she married singer Freddy Moore, who is 12 years her senior, adopting his surname. The marriage lasted for four years.
In 1987, Moore married actor Bruce Willis. They had three daughters together: Rumer Glenn Willis , Scout LaRue Willis , and Tallulah Belle Willis. Moore and Willis divorced in 2000.
In the mid-1980s, Moore appeared in the youth-oriented films 'St Elmo's Fire', 'Blame It on Rio' and 'About Last Night...'.
However, Moore was not widely known until she played the part of Jackie Templeton on the ABC soap opera, 'General Hospital', from 1982 to 1983.
Moore was born Demi Gene Guynes in Roswell, New Mexico. As a child, she had a difficult and unstable home life.
His debut film role was in the comedic sci-fi horror film 'Critters 3', in which he played the stepson of an evil landlord, a role that DiCaprio described as your average, no-depth, standard kid with blond hair."
In 1990, he got his break on television when he was cast in the short-lived series based on the movie 'Parenthood'.
In August 1991, Moore appeared nude on the cover of Vanity Fair under the title 'More Demi Moore'.
The same year, DiCaprio reunited with Kate Winslet to film the drama 'Revolutionary Road' (2008), directed by Winslet's then-husband Sam Mendes.
DiCaprio continued his run with Scorsese in the 2010 psychological thriller film 'Shutter Island' (2010), based on the 2003 novel of the same name by Dennis Lehane.
'Inception' was a huge hit. With loads of other plum roles up his sleeves - Leonardo DiCaprio can have a splendid year ahead.
After the commercial success of 'Ghost', Moore was given more prominent roles in 'A Few Good Men', 'Indecent Proposal', 'Disclosure', and 'The Hunchback of Notre Dame' for which she was the first actress to reach the $10 million salary mark.
After training with John Casablancas, the founder of Elite Model Management, Moore made her film debut in the 1982 3-D science fiction/horror film, 'Parasite', which was a hit on the drive-in circuit, ultimately grossing $7 million.
In 1996, DiCaprio appeared opposite Claire Danes in Baz Luhrmann's film 'Romeo Juliet', an abridged modernization of William Shakespeare's romantic tragedy of the same name which retained the original Shakespearean dialogue.
After 'Parenthood', DiCaprio had bit parts on several shows, including 'The New Lassie' and 'Roseanne', as well as a brief stint on the soap opera 'Santa Barbara', playing the young Mason Capwell.
In 1998 he starred in the dual roles of the villainous King Louis XIV and his secret, sympathetic twin brother Philippe in Randall Wallace's 'The Man in the Iron Mask', based on the same-titled 1939 film.
DiCaprio made his big screen breakthrough in 1992, when he was handpicked by Robert De Niro out of 400 young actors to play the lead role in 'This Boy's Life', co-starring Ellen Barkin and De Niro himself.
In the 1990's she had a string of less successful films like 'The Scarlet Letter', 'The Juror', 'Striptease', and 'GI Jane'.
Against expectations, the film went on to become the highest-grossing film to date (it was surpassed in 2010 by Cameron's directorial follow-up, Avatar), grossing more than US$ 1.843 billion in box-office receipts worldwide, and transformed DiCaprio into a commercial movie superstar, resulting in fan worship among teenage girls and young women in general that became known as 'Leo-Mania'.
DiCaprio's next project was the drama film 'The Beach' (2000), an adaption of Alex Garland's same-titled 1996 novel.
Cast as twenty-year-old Jack Dawson, a penniless Wisconsin man who wins two tickets for the third-class on the fated RMS Titanic, DiCaprio initially refused to portray the character but was eventually encouraged to pursue the role by Cameron who strongly believed in his acting ability.
DiCaprio's first film of 2002 was the crime-comedy 'Catch Me If You Can', based on the life of Frank Abagnale Jr, who, before his 19th birthday, used his charm, confidence, and several different personas, to make millions in the 1960s writing bad checks.
In 2002, DiCaprio appeared in Martin Scorsese's 'Gangs of New York', a historical film set in the mid-19th century in the Five Points district of New York City.
Forging a collaboration with Scorsese, the two paired again for a biopic of the eccentric and obsessive American film director and aviation pioneer Howard Hughes in 'The Aviator' (2004).
Later in 1993, DiCaprio co-starred as the mentally handicapped brother to Johnny Depp in 'What's Eating Gilbert Grape', a comic-tragic odyssey of a dysfunctional Iowa family.
In Edward Zwick's war film 'Blood Diamond', he co-starred alongside Jennifer Connelly and Djimon Hounsou as a diamond smuggler from Rhodesia who is involved in the Sierra Leone Civil War.
In 2008, DiCaprio starred in 'Body of Lies', a spy film based on the novel of the same name by David Ignatius, set in context of the Middle East and the War on Terror, unfolding the story of three men battling a terrorist organization, and each other.
Annie Leibovitz shot the picture while Moore was seven months pregnant with her daughter Scout LaRue, intending to portray 'anti-Hollywood, anti-glitz' attitude.
After a break from her acting career, Moore returned to the screen as the villain of the 2003 film 'Charlie's Angels: Full Throttle'.